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Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test-retest.

Petit-Demouliere B, Bourin M

EA 3256 Neurobiologie de l'anxiété et de la dépression, Faculté de Médecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France.

Anxiolytic-like effect of diazepam is abolished by a previous exposure to four-plate test (FPT). Variations of temporal parameters: interval between trials and duration of Trial 1, with or without electric punishments allow characterizing factors which are responsible for this loss phenomenon. Complete spatial representation of FPT seems to be responsible of this one-trial tolerance, and needs at least a 30s exposure to the apparatus to be completed, with or without punishments.

Published 10 September 2007 in Behav Brain Res, 183(2): 222-5.
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