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Status gelasticus associated with levetiracetam as add-on treatment.

Pustorino G, Spano M, Sgro DL, Di Rosa G, Tricomi G, Bellantone D, Tortorella G

Unit of Child Neuropsychiatry, Dept of Medical and Surgical Pediatrics, University Hospital, Messina, Italy.

We report the case of a five-year-old girl, presenting with difficult-to-treat, symptomatic focal epilepsy, who developed status gelasticus following the introduction of levetiracetam as add-on treatment to oxcarbazepine and diazepam. Gelastic seizures were documented by video-EEG and were responsive to i.v. administration of diazepam. A possible causative role of levetiracetam is suggested. Specific susceptibility to some AEDs is also discussed, as this patient, at the age of four years, had presented an episode of non-convulsive status epilepticus, following introduction of tiagabine, in association with vigabatrin and nitrazepam.[Published with video sequences].

Published 25 May 2007 in Epileptic Disord, 9(2): 186-9.
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