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Neuropharmacological activity of Eupatorium buniifolium aqueous extract in mice.

Miño J, Muschietti L, Ferraro G, Martino V, Acevedo C

Cátedra de Farmacología, Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113AAD), Buenos Aires, Argentina.

The aim of this study was to evaluate the neuropharmacological profile of the Eupatorium buniifolium aqueous extract (EB) in mice. EB at doses up to 1.5 g/kg p.o. of the lyophilized material produced a dose dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital, respectively. However, EB neither modified the spontaneous motor activity nor produced a myorelaxant effect. Moreover, EB 1.5 g/kg in a nose-poke habituation task, produced a disruption of the normal patterns of habituation, and in a step-down inhibitory avoidance task, induced an amnesic effect similar to diazepam. These results suggest that the activity of EB may be a CNS-depressant.

Published 28 March 2007 in Phytother Res, 21(4): 362-5.
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