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Anxiolytic effects of Salvia reuterana Boiss. on the elevated plus-maze model of anxiety in mice.

Rabbani M, Sajjadi SE, Jafarian A, Vaseghi G

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran.

The anxiolytic and sedative effects of hydroalcoholic extract (HE) of Salvia reuterana Boiss. was evaluated in mice. The HE of Salvia reuterana (100 mg/kg), increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze. Spontaneous locomotor activity count measured in 15 min of the test was significantly decreased in animals pretreated with diazepam and 100 mg/kg of Salvia reuterana extract. Results of the present study provide support for the traditional usage of Salvia reuterana as a sedative and anxiolytic medicinal plant.

Published 12 September 2005 in J Ethnopharmacol, 101(1): 100-3.
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