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Long-term impaired memory following predatory stress in mice.

El Hage W, Griebel G, Belzung C

EA3248 and IFR135, Université François Rabelais, Faculté Sciences et Techniques, Parc Grandmont, 37200 Tours, France. el-hage@med.univ-tours.fr

Brief exposure of mice to unavoidable predatory stimuli is associated with behavioral and neurochemical changes consistent with increased anxiety and produces short-term impaired learning restored by acute fluoxetine treatment, but not by diazepam. The present study investigated long-lasting changes induced by a unique unavoidable cat exposure in BALB/c mice on learning abilities using learning tests (radial maze, spatial configuration of objects recognition test). Results from the group comparison showed that predatory exposure induced significant learning disabilities in the radial maze (16 to 22 days poststressor) and in the spatial configuration of objects recognition test (26 to 28 days poststressor). These findings indicate that memory impairments may persist for extended periods beyond a predatory stress. This animal model of unique exposure of mice to unavoidable predatory stimuli has proven to be a useful model for the study of reactions to traumatic stress.

Published 19 December 2005 in Physiol Behav, 87(1): 45-50.
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